منابع مشابه
Phosphorylation for break repair
A constitutive, phosphate-based interaction between two repair proteins may help provide instant, well-coordinated repair of double-stranded DNA (dsDNA) breaks, according to two articles in this issue from Melander et al. and Spycher et al. Nearly every step in dsDNA break repair requires MRN, from recognizing the break to activating signaling pathways to the mechanics of repair—or apoptosis, i...
متن کاملPhosphorylation: The Molecular Switch of Double-Strand Break Repair
Repair of double-stranded breaks (DSBs) is vital to maintaining genomic stability. In mammalian cells, DSBs are resolved in one of the following complex repair pathways: nonhomologous end-joining (NHEJ), homologous recombination (HR), or the inclusive DNA damage response (DDR). These repair pathways rely on factors that utilize reversible phosphorylation of proteins as molecular switches to reg...
متن کاملChk2 phosphorylation of BRCA1 regulates DNA double-strand break repair.
The pathway determining malignant cellular transformation, which depends upon mutation of the BRCA1 tumor suppressor gene, is poorly defined. A growing body of evidence suggests that promotion of DNA double-strand break repair by homologous recombination (HR) may be the means by which BRCA1 maintains genomic stability, while a role of BRCA1 in error-prone nonhomologous recombination (NHR) proce...
متن کاملLZAP Inhibits p38 MAPK (p38) Phosphorylation and Activity by Facilitating p38 Association with the Wild-Type p53 Induced Phosphatase 1 (WIP1)
LZAP (Cdk5rap3, C53) is a putative tumor suppressor that inhibits RelA, Chk1 and Chk2 and activates p53. LZAP is lost in a portion of human head and neck squamous cell carcinoma and experimental loss of LZAP expression is associated with enhanced invasion, xenograft tumor growth and angiogenesis. p38 MAPK can increase or decrease proliferation and cell death depending on cellular context. LZAP ...
متن کاملStudy Break: Bacterial Cancer
Rarely, do we think of cancer as “bacterial”, such that we are often told that “cancer is NOT contagious” Persistent bacterial infections cause persistent irritation of the host’s defense systems, which when ineffective in eradication of the infection, result in a multitude of self-destructive damages. This in some cases occurs to such severity that the resu...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2017
ISSN: 1538-4101,1551-4005
DOI: 10.1080/15384101.2017.1285632